Since 1967 when ISI was ASTI Denpasar, it has been experienced several periods of leadership successions till for period of 2017. However, through such experiences ISI is now a lot stronger and flourished as the world of education is as well changing rapidly. In the future ISI is believed to be able to play significant roles on the developments of science, technology, and art matters. The cycle of those leadership successions can be depicted in the following table;
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| No | Name | Position | Period |
| 1. | I Wayan Mertha Sutedja, BA. | Director of ASTI Denpasar | 1967 – 1978 |
| 2. | Dr. I Made Bandem., MA. | Director of ASTI Denpasar | 1978 – 1986 |
| 3. | Prof. Dr. I Made Bandem, MA. | Chairman of STSI Denpasar | 1986 – 1997 |
| 4. | Prof. Dr. I Wayan Dibia, SST., MA. | Chairman of STSI Denpasar | 1997 – 2002 |
| 5. | Dr. I Wayan Rai S., MA. | Chairman of STSI Denpasar | 2002 – 2004 |
| 6. | Drs. Anak Agung Rai Kalam | Chairman PSSRD Udayana | 1983 – 1991 |
| 7. | Drs. I Made Subrata.,M.Si. | Chairman PSSRD Udayana | 1991 – 1999 |
| 8. | Drs. Nyoman Sukaya. | Chairman PSSRD Udayana | 1999 – 2004 |
| 9. | Prof. Dr. I Wayan Rai S., MA. | Rector of ISI Denpasar | 2004 – 2008 |
| 10. | Prof. Dr. I Wayan Rai S., MA | Rector of ISI Denpasar | 2009 – 2013 |
| 11. | Dr. I Gede Arya Sugiartha, S.Skar., Hum | Rector of ISI Denpasar | 2013 – 2017 |